Kids with arthritis in less affluent families report longer period of morning stiffness

Children with arthritis affecting five or more joints, called polyarticular juvenile idiopathic arthritis (polyarticular JIA), living in less affluent families were twice as likely to report more than an hour of morning joint stiffness, compared to their counterparts from more affluent families, according to a study by investigators at Hospital for Special Surgery (HSS). Parents […]

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Investigators discover unique immune cells in patients with checkpoint inhibitor-induced arthritis

Since doctors began treating cancer patients with immunotherapy drugs called checkpoint inhibitors nearly a decade ago, they have observed that a subset of these patients experience a side effect that clinically looks like inflammatory arthritis. These drugs, which take the natural brake off immune cells called T cells and allow them to attack cancer, can […]

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Improving the diagnosis of chronic nonbacterial osteomyelitis

Researchers have identified several factors that should help improve the diagnosis of chronic nonbacterial osteomyelitis (CNO), also known as chronic recurrent multifocal osteomyelitis (CRMO). This chronic autoinflammatory syndrome, which can be debilitating, is underdiagnosed and is characterized by multiple foci of painful swelling of bones, mainly in the metaphyses of the long bones, in addition […]

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Scientists discover a brain circuit that signals the direction and distance of boundaries in the environment

We perceive the world relative to our own body from a self-centered perspective. Yet our brain is able to transform this information into a world-centered, cognitive map of the environment, guiding us independent of where we look or the direction we face. The mechanism behind this has remained unsolved for decades. Now scientists at the […]

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Novel therapy approach for hyperinsulinemic hypoglycemia

A new method to treat hyperinsulinemic hypoglycemia has proven highly selective in targeting lesions and effective in slowing tumor growth, according to research published in the November issue of the Journal of Nuclear Medicine. The novel approach utilizes receptor-targeted photodynamic therapy with exendin-4-IRDye700DX to induce phototoxicity in insulin-producing cells that cause hyperinsulinemic hypoglycemia. Insulin production […]

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